Resveratrol

Resveratrol Supplements

Growing Evidence Links Resveratrol to Extended Life Span

Resveratrol has continued to demonstrate extraordinary potential in prolonging life. In numerous studies-including those at BioMarker Pharmaceuticals -- resveratrol has demonstrated effects that mimic those of caloric restriction, the best-documented anti-aging strategy to date. In all animals in which it has been tested, caloric restriction-the practice of restricting calorie intake while maintaining good nutritional status-improves multiple aspects of age-related decline.

Caloric restriction does this, in part, by producing changes in gene expression that are associated with long life and a slowing of the aging process.   

Resveratrol is also gaining growing recognition for its promise in fighting age-related diseases ranging from dementia to diabetes. For example, the National Institutes of Health is currently sponsoring a clinical trial investigating resveratrol's ability to fight colon cancer.
In this article, we bring our readers up to date on the latest clinical research on resveratrol, and why leading researchers believe this remarkable nutrient may hold the key to living a longer, more vibrant, disease-free life.

Resveratrol

Resveratrol and Caloric Restriction

To date, the most reliable, best-researched way to extend life span is through the practice of caloric restriction, which involves reducing calorie intake while simultaneously maintaining good nutritional status.
In numerous studies, restricting calorie intake in laboratory animals has been shown to prolong their life span by as much as 60%. While scientists have not yet determined whether caloric restriction extends life span in humans, the preliminary evidence is very promising. In humans, consuming a low-calorie diet is associated with several possible markers of greater longevity, such as lower insulin levels and reduced body temperatures, along with less of the chromosomal damage that typically accompanies aging. Furthermore, people who consume a low-calorie diet may be less prone to diseases associated with being overweight or obese, such as metabolic syndrome, diabetes, cancer, and atherosclerosis.

Although caloric restriction may be effective in promoting longevity, the problem is that most adults find this stringent lifestyle strategy to be impractical. As a result, scientists have sought to uncover the precise mechanisms by which caloric restriction promotes longevity, in order to help people capture its life-extending benefits through more practical means.

Resveratrol Offsets Perils of a High-Calorie Diet

Remarkable new research suggests that it may be possible to achieve the life-extending benefits of caloric restriction using the readily available, plant-derived compound known as resveratrol. Resveratrol and caloric restriction appear to work via similar mechanisms to promote health and longevity in numerous animal species.

In an interview, a leading resveratrol researcher, Dr. Xi Zhao-Wilson of BioMarker Pharmaceuticals, told Life Extension, "There has been a great deal of attention focused on resveratrol in the past few years, following a study showing that resveratrol activates molecular pathways involved in life-span extension, now demonstrated in yeast, worms, flies, fish, and mice, and which possibly bear a relationship to mechanisms under-lying caloric restriction."

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